DISPOSITION OF FLUMEQUINE IN PLASMA OF EUROPEAN EEL (ANGUILLA-ANGUILLA) AFTER A SINGLE INTRAMUSCULAR INJECTION

被引：22

作者：

BOON, JH

NOUWS, JMF

VANDERHEIJDEN, MHT

BOOMS, GHR

DEGEN, M

机构：

[1] Department of Fish Culture and Fisheries, Wageningen Agricultural University, 6700 AH Wageningen

[2] R V. V.-District 6, P.O. Box 40010

来源：

AQUACULTURE | 1991年 / 99卷 / 3-4期

关键词：

D O I：

10.1016/0044-8486(91)90242-Y

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

The plasma disposition and the excretion of flumequine, a second generation quinoline derivative, was studied in eel after a single intramuscular administration of 9 mg kg-1. Pharmacokinetic analysis of the plasma concentrations showed that the flumequine formulation exhibited an extended absorption and elimination half-life of about 33 and 255 h respectively. Slow rates of absorption and tissue distribution, and the absence of biotransformation and active excretion may explain the long drug persistence. This must have consequences for the determination of a proper withdrawal time after treatment of consumable eels with flumequine.

引用

页码：213 / 223

页数：11

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