PROGNOSIS OF OSTEOSARCOMA TREATED BY LIMB-SALVAGE SURGERY - THE 10-YEAR INTERGROUP STUDY IN JAPAN

被引:26
作者
TSUCHIYA, H
TOMITA, K
机构
[1] Department of Orthopedic Surgery, School of Medicine, Kanazawa University, Kanazawa, 920
[2] School of Medicine, Hokkaido University
[3] Hirosaki University, School of Medicine
[4] Surugadai Hospital, Nihon University
[5] Nihon University, School of Medicine
[6] Juntendo University, School of Medicine
[7] School of Medicine, Chiba University
[8] School of Medicine, Gunma Univesity
[9] School of Medicine, Gifu University
[10] Toyama Medical, Pharmaceutical University
[11] The Center for Adult Diseases, Osaka
[12] School of Medicine, Fukuoka University
[13] School of Medicine, University of the Ryukyus
关键词
OSTEOSARCOMA; LIMB-SALVAGE SURGERY; PROGNOSIS;
D O I
10.1093/oxfordjournals.jjco.a039576
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We report the prognoses for 107 patients treated by limb-salvage surgery and 147 treated by amputation or disarticulation, during the period 1980-1985, at 22 university hospitals, cancer centers and national hospitals in Japan. In this multi-institute non-randomized study, the five-year cumulative survival rate was 70% for the former group and 49% for the latter. The prognosis was more favorable among patients who responded to preoperative chemotherapy than among those who did not. Limb-salvage surgery was feasible for most of the surgical stage IIB patients with small extraosseous tumor extensions who had responded to preoperative chemotherapy. Local tumor recurrences were seen in 15 (14%) of the 107 patients in the limb-salvage surgery group, nine of whom died of the metastasis. While limb-salvage surgery is being increasingly used in Japan, present indications show the procedure not to reduce survival rate for osteosarcoma patients. The survival rate of patients with wide-with-marginal margins was similar to that of patients with wide margins. Taking into account the long-term survival of osteosarcoma patients, limb-salvage surgery can be recommended when the osteosarcoma responds to preoperative chemotherapy.
引用
收藏
页码:347 / 353
页数:7
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