ACETOGENIC ISOQUINOLINE ALKALOIDS .69. BIOMIMETIC OXIDATIVE DIMERIZATION OF KORUPENSAMINE A - COMPLETION OF THE FIRST TOTAL SYNTHESIS OF MICHELLAMINE-A, MICHELLAMINE-B, AND MICHELLAMINE-C

被引：57

作者：

BRINGMANN, G ^{[1
]}

HARMSEN, S ^{[1
]}

HOLENZ, J ^{[1
]}

GEUDER, T ^{[1
]}

GOTZ, R ^{[1
]}

KELLER, PA ^{[1
]}

WALTER, R ^{[1
]}

HALLOCK, YF ^{[1
]}

CARDELLINA, JH ^{[1
]}

BOYD, MR ^{[1
]}

机构：

[1] NCI,DRUG DISCOVERY RES & DEV LAB,FREDERICK,MD 21702

来源：

TETRAHEDRON | 1994年 / 50卷 / 32期

关键词：

D O I：

10.1016/S0040-4020(01)85532-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A first synthetic access to michellamine A (1), a C-2-symmetric antiviral naturally occurring quateraryl, is described, by oxidative 'dimerization' of an appropriately protected 'monomeric' naphthylisoquinoline alkaloid, named korupensamine A (2). Due to the synthetic availability of 2 recently achieved and given the published interconversion of michellamines A - C, this coupling reaction simultaneously represents the completion of a first total synthesis of a representative and thus of all hitherto known michellamines.

引用

页码：9643 / 9648

页数：6

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