INTERLEUKIN-8 INDUCES HLA-DR EXPRESSION ON CULTURED HUMAN KERATINOCYTES VIA SPECIFIC RECEPTORS

被引：14

作者：

KEMENY, L

KENDERESSY, AS

OCSOVSZKY, I

MICHEL, G

RUZICKA, T

DOBOZY, A

机构：

[1] ALBERT SZENT GYORGYI MED UNIV,DEPT BIOCHEM,H-6701 SZEGED,HUNGARY

[2] UNIV DUSSELDORF,DEPT DERMATOL,W-4000 DUSSELDORF,GERMANY

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 106卷 / 04期

关键词：

CYTOKINES; INTERLEUKIN-8; SKIN IMMUNE SYSTEM;

D O I：

10.1159/000236866

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 [免疫学];

摘要：

Recent studies suggest that interleukin (IL)-8 exerts a direct influence on several functions such as the chemotaxis or proliferation of human keratinocytes (HK). Since the effects of IL-8 in skin are mediated through specific receptors, we have studied the characteristics of the keratinocyte IL-8 receptor. We could identify specific binding sites for IL-8 in cultured HKs by flow cytometry. Pretreatment of the cells with tumor necrosis factor (TNF)-alpha or IL-1 alpha resulted in a significant increase in IL-8 binding. IL-8 selectively induced expression of HLA-DR antigen, but had no effect on the expression of other cell surface antigens (CD11a, CD18, CD36 and CD54).

引用

页码：351 / 356

页数：6

共 29 条

[1]

DEFECT OF EPIDERMAL 12(S)-HYDROXYEICOSATETRAENOIC ACID RECEPTORS IN PSORIASIS [J].