Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)

被引：16

作者：

Cauli, Alberto ^{[1
]}

Piga, Matteo ^{[1
]}

Floris, Alberto ^{[1
]}

Mathieu, Alessandro ^{[1
]}

机构：

[1] Policlin Univ Cagliari, Rheumatol Unit, Dept Med Sci, Ss554, I-090142 Cagliari, Italy

来源：

IMMUNOTARGETS AND THERAPY | 2015年 / 4卷

关键词：

TH17; IL-17; IL-23; psoriasis; psoriatic arthritis; ankylosing spondylitis;

D O I：

10.2147/ITT.S62870

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

TH17 is a lymphocyte subset, which is characterized by its polarization to secrete interleukin (IL)-17. IL-23 is the pivotal mediator responsible for TH17 differentiation and the IL-23/IL-17 axis has been strongly implicated in the pathogenesis of several immune mediated diseases, in particular chronic arthritis and skin psoriasis. This review will summarize the basic immunology and the new monoclonal antibodies, which antagonize this pathway allowing a new therapeutic approach.

引用

页码：185 / 190

页数：6

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