HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING

被引：1069

作者：

FERSHT, AR

SHI, JP

KNILLJONES, J

LOWE, DM

WILKINSON, AJ

BLOW, DM

BRICK, P

CARTER, P

WAYE, MMY

WINTER, G

机构：

[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT PHYS,LONDON SW7 2AY,ENGLAND

[2] MRC CTR,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

NATURE | 1985年 / 314卷 / 6008期

关键词：

D O I：

10.1038/314235a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：235 / 238

页数：4

共 23 条

[1] TYROSYL-TRANSFER RNA-SYNTHETASE FORMS A MONONUCLEOTIDE-BINDING FOLD
BHAT, TN
BLOW, DM
BRICK, P
NYBORG, J
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1982, 158 (04) : 699 - 709
[2] BLOW DM, 1985, BIOL MACROMOL, V2, P442
[3] Cantor C. R., 1980, BIOPHYSICAL CHEM 1, P277
[4] THE USE OF DOUBLE MUTANTS TO DETECT STRUCTURAL-CHANGES IN THE ACTIVE-SITE OF THE TYROSYL-TRANSFER RNA-SYNTHETASE (BACILLUS-STEAROTHERMOPHILUS)
CARTER, PJ
WINTER, G
WILKINSON, AJ
FERSHT, AR
[J]. CELL, 1984, 38 (03) : 835 - 840
[5] FERSHT A, 1985, ENZYME STRUCTURE MEC, pCH2
[6] PROBING THE LIMITS OF PROTEIN-AMINO ACID SIDE-CHAIN RECOGNITION WITH THE AMINOACYL-TRANSFER RNA-SYNTHETASES - DISCRIMINATION AGAINST PHENYLALANINE BY TYROSYL-TRANSFER RNA-SYNTHETASES
FERSHT, AR
SHINDLER, JS
TSUI, WC
[J]. BIOCHEMISTRY, 1980, 19 (24) : 5520 - 5524
[7] DEMONSTRATION OF 2 REACTION PATHWAYS FOR AMINOACYLATION OF TRANSFER-RNA - APPLICATION OF PULSED QUENCHED FLOW TECHNIQUE
FERSHT, AR
JAKES, R
[J]. BIOCHEMISTRY, 1975, 14 (15) : 3350 - 3356
[8] CYSTEINYL-TRANSFER RNA-SYNTHETASE FROM ESCHERICHIA-COLI DOES NOT NEED AN EDITING MECHANISM TO REJECT SERINE AND ALANINE - HIGH BINDING-ENERGY OF SMALL-GROUPS IN SPECIFIC MOLECULAR-INTERACTIONS
FERSHT, AR
DINGWALL, C
[J]. BIOCHEMISTRY, 1979, 18 (07) : 1245 - 1249
[9] EVIDENCE FOR THE DOUBLE-SIEVE EDITING MECHANISM IN PROTEIN-SYNTHESIS - STERIC EXCLUSION OF ISOLEUCINE BY VALYL-TRANSFER RNA-SYNTHETASES
FERSHT, AR
DINGWALL, C
[J]. BIOCHEMISTRY, 1979, 18 (12) : 2627 - 2631
[10] ANALYSIS OF ENZYME STRUCTURE AND ACTIVITY BY PROTEIN ENGINEERING
FERSHT, AR
SHI, JP
WILKINSON, AJ
BLOW, DM
CARTER, P
WAYE, MMY
WINTER, GP
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1984, 23 (07): : 467 - 473

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