A NOVEL SOLVENT SYSTEM FOR SOLID-PHASE SYNTHESIS OF PROTECTED PEPTIDES - THE DISAGGREGATION OF RESIN-BOUND ANTIPARALLEL BETA-SHEET

被引：48

作者：

HENDRIX, JC ^{[1
]}

HALVERSON, KJ ^{[1
]}

JARRETT, JT ^{[1
]}

LANSBURY, PT ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 15期

关键词：

D O I：

10.1021/jo00302a009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

: This paper reports the application of the solvent system of lithium bromide in tetrahydrofuran for the disaggregation of protected peptide bound to the Kaiser oxime resin. Fourier-transform infrared spectroscopy is used to characterize the aggregating structure and to follow the disaggregation. The solvation of resin-bound peptide has practical consequences in that the yield of the nucleophilic cleavage of protected peptides from the Kaiser resin is greatly increased. © 1990, American Chemical Society. All rights reserved.

引用

页码：4517 / 4518

页数：2

共 20 条

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