PROSTAGLANDIN PRODUCTION IN CHRONIC PROGRESSIVE MULTIPLE-SCLEROSIS

被引：12

作者：

ABERG, JA ^{[1
]}

DEMERS, LM ^{[1
]}

ROMANO, PJ ^{[1
]}

TENSER, RB ^{[1
]}

机构：

[1] PENN STATE COLL MED,DEPT PATHOL,POB 850,HERSHEY,PA 17033

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 1990年 / 4卷 / 04期

关键词：

multiple sclerosis; Prostaglandin production;

D O I：

10.1002/jcla.1860040403

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Peripheral blood monocytes have been implicated in the immune reactions that accompany demyelination in patients with multiple sclerosis (MS). We measured prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) release from peripheral monocytes exposed in vitro to complement. Our studies suggest that there is a significantly higher production of PGE2 in monocytes from patients with chronic progressive MS than in those with exacerbation or remitting MS and healthy controls. No significant differences in TxB2release were noted between the three groups. Copyright © 1990 Wiley Periodicals, Inc., A Wiley Company

引用

页码：246 / 250

页数：5

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