NEUTRAL SURFACE AMINOPEPTIDASE ACTIVITY OF HUMAN TUMOR-CELL LINES

被引：21

作者：

AMOSCATO, AA

SRAMKOSKI, RM

BABCOCK, GF

ALEXANDER, JW

机构：

[1] UNIV CINCINNATI,DEPT SURG,CINCINNATI,OH 45221

[2] SHRINERS BURN INST,CINCINNATI,OH 45219

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1041卷 / 03期

关键词：

AMINOPEPTIDASE; TUMOR CELL LINE; (HUMAN);

D O I：

10.1016/0167-4838(90)90291-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven human tumor cell lines were studied for their neutral surface aminopeptidase (AP) activity. The activity was shown to exist on all cell lines to varying degrees. The neutral AP activity of the cell lines had similar K(m) values and were affected by the same inhibitors as those reported for AP's of peripheral blood lymphocytes (PBL, Refs. 1 and 2). However, a difference was seen in the V(max) values of the various cell lines. These values were shown to correlate (r = 0.767, P < 0.05) with cell surface area.

引用

页码：317 / 319

页数：3