INHIBITION OF DUCK HEPATITIS-B VIRUS-INFECTION BY LYSOSOMOTROPIC AGENTS

被引：31

作者：

OFFENSPERGER, WB ^{[1
]}

OFFENSPERGER, S ^{[1
]}

WALTER, E ^{[1
]}

BLUM, HE ^{[1
]}

GEROK, W ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,CTR CANC,GASTROINTESTINAL UNIT & MOLEC HEPATOL,BOSTON,MA 02129

来源：

VIROLOGY | 1991年 / 183卷 / 01期

关键词：

D O I：

10.1016/0042-6822(91)90157-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The early phases of hepadnaviral infection were studied in primary duck hepatocyte cultures. Incubation of duck hepatocytes in vitro with duck hepatitis B virus (DHBV) resulted in infection with high levels of viral replication. The lysosomotropic agents ammonium chloride and chloroquine effectively inhibited viral infection, indicating that DHBV infection, similar to infection with other enveloped viruses, depends on receptor-mediated endocytosis and involves membrane fusion triggered by low pH. © 1991.

引用

页码：415 / 418

页数：4

共 27 条

[1] ANTIVIRAL STRATEGIES IN CHRONIC HEPATITIS-B VIRUS-INFECTION .1. ESTABLISHMENT OF AN INVITRO SYSTEM USING THE DUCK HEPATITIS-B VIRUS MODEL [J].

BISHOP, N ;

CIVITICO, G ;

WANG, YY ;

GUO, KJ ;

BIRCH, C ;

GUST, I ;

LOCARNINI, S .

JOURNAL OF MEDICAL VIROLOGY, 1990, 31 (02) :82-89

[2] ASYMMETRIC REPLICATION OF HEPATITIS-B VIRUS-DNA IN HUMAN-LIVER - DEMONSTRATION OF CYTOPLASMIC MINUS-STRAND DNA BY BLOT ANALYSES AND INSITU HYBRIDIZATION [J].

BLUM, HE ;

HAASE, AT ;

HARRIS, JD ;

WALKER, D ;

VYAS, GN .

VIROLOGY, 1984, 139 (01) :87-96

[3]

CANNING WM, 1982, SCIENCE, V219, P987

[4] ANTIVIRAL STRATEGIES IN CHRONIC HEPATITIS-B VIRUS-INFECTION .2. INHIBITION OF DUCK HEPATITIS-B VIRUS INVITRO USING CONVENTIONAL ANTIVIRAL AGENTS AND SUPERCOILED-DNA ACTIVE COMPOUNDS [J].

CIVITICO, G ;

WANG, YY ;

LUSCOMBE, C ;

BISHOP, N ;

TACHEDJIAN, G ;

GUST, I ;

LOCARNINI, S .

JOURNAL OF MEDICAL VIROLOGY, 1990, 31 (02) :90-97

[5]

DEDUVE C, 1983, EUR J BIOCHEM, V137, P391, DOI 10.1111/j.1432-1033.1983.tb07841.x

[6]

DOMS RW, 1985, J BIOL CHEM, V260, P2973

[7] PROLONGED DUCK HEPATITIS-B VIRUS-REPLICATION IN DUCK HEPATOCYTES COCULTIVATED WITH RAT EPITHELIAL-CELLS - A USEFUL SYSTEM FOR ANTIVIRAL TESTING [J].

FOUREL, I ;

GRIPON, P ;

HANTZ, O ;

COVA, L ;

LAMBERT, V ;

JACQUET, C ;

WATANABE, K ;

FOX, J ;

GUILLOUZO, C ;

TREPO, C .

HEPATOLOGY, 1989, 10 (02) :186-191

[8] EFFECTS OF ADENINE-ARABINOSIDE ON SERUM AND INTRAHEPATIC REPLICATIVE FORMS OF DUCK HEPATITIS-B VIRUS IN CHRONIC INFECTION [J].

HIROTA, K ;

SHERKER, AH ;

OMATA, M ;

YOKOSUKA, O ;

OKUDA, K .

HEPATOLOGY, 1987, 7 (01) :24-28

[9] INHIBITION OF DUCK HEPATITIS-B VIRUS-REPLICATION BY 2',3'-DIDEOXYCYTIDINE - A POTENT INHIBITOR OF REVERSE-TRANSCRIPTASE [J].

KASSIANIDES, C ;

HOOFNAGLE, JH ;

MILLER, RH ;

DOO, E ;

FORD, H ;

BRODER, S ;

MITSUYA, H .

GASTROENTEROLOGY, 1989, 97 (05) :1275-1280

[10] MEMBRANE-FUSION MUTANTS OF SEMLIKI FOREST VIRUS [J].

KIELIAN, MC ;

KERANEN, S ;

KAARIAINEN, L ;

HELENIUS, A .

JOURNAL OF CELL BIOLOGY, 1984, 98 (01) :139-145

← 1 2 3 →