SYNTHESES OF 2,6-DIDEOXY-6-FLUORO-2-[(3R AND 3S)-3-HYDROXYTETRADECANAMIDO]-3-O-[(3R)-3-(TETRADECANOLYOXY)-TETRADECANOYL]-D-GLUCOPYRANOSE 4-(DIHYDROGEN PHOSPHATE) AND 2-DEOXY-2-[(3R AND 3S)-3-HYDROXYTETRADECANAMIDO]-3-O-[(3R)-3-(TETRADECANOYLOXY)TETRADECANOYL]-ALPHA-D-GLUCOPYRANOSYL FLUORIDE 4-(DIHYDROGEN PHOSPHATE) - FLUOROSUGAR ANALOGS OF GLA-60

被引：4

作者：

KOBAYASHI, Y

ISHIDA, N

ARAI, M

SHIOZAKI, M

HIRAOKA, T

NISHIJIMA, M

KUGE, S

OTSUKA, T

AKAMATSU, Y

机构：

[1] SANKYO CO LTD,NEW LEAD RES LABS,HIROMACHI 1-2-58,SHINAGAWA KU,TOKYO 140,JAPAN

[2] NATL INST HLTH,DEPT CHEM,SHINAGAWA KU,TOKYO 141,JAPAN

来源：

CARBOHYDRATE RESEARCH | 1991年 / 222卷

关键词：

D O I：

10.1016/0008-6215(91)89008-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Both 2,6-dideoxy-6-fluoro-2-[(3R)- and (3S)-3-hydroxytetradecanamido]-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-D-glucopyranose 4-phosphate, 11 and 11' (6-fluoro GLA-60 and its 3'-epimer), and 2-deoxy-2[(3R)- and (3S)-(3-hydroxytetradecanamido]-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-alpha-D-glucopyranosyl fluoride 4-(dihydrogen phosphate), 18 and 18' (1-fluoro GLA-60 and its 3'-epimer), were synthesized from ally 2-deoxy-4,6-O-isopropylidene-2-trifluoroacetamido-alpha-D-glucopyranoside.

引用

页码：83 / 97

页数：15

共 14 条

[1]

ASCHAUER H, 1990, J BIOL CHEM, V265, P9159

[2] STUDIES OF SYNTHESIS AND CONFORMATION IN D-RIBOPYRANOSE SERIES [J].