SEQUENCES INVOLVED IN BRAIN-SPECIFIC INVITRO TRANSCRIPTION FROM THE CORE PROMOTER OF THE MOUSE MYELIN BASIC-PROTEIN GENE

被引：12

作者：

TAMURA, TA

SUMITA, K

MIKOSHIBA, K

机构：

[1] NATL INST BASIC BIOL, DIV BEHAV & NEUROBIOL, OKAZAKI, AICHI 444, JAPAN

[2] OSAKA UNIV, INST PROT RES, DIV MACROMOLEC FUNCT, SUITA, OSAKA 565, JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1129卷 / 01期

关键词：

TATA-BOX; MYELIN BASIC PROTEIN; CORE PROMOTER; TRANSCRIPTION FACTOR; (MOUSE);

D O I：

10.1016/0167-4781(91)90215-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the previous study, we have shown that a short DNA stretch from -35 to -17 in the core promoter of the mouse myelin basic protein (MBP) gene is mainly responsible for brain-specificity in in vitro transcription. In this study, we found from intensive mutation analyses that the TATA-box sequence at -34 is not critical, but sequences downstream from the TATA-box especially around -20 were important for brain-specificity. The existence of a tissue-specific factor for the MBP core promoter different from the TATA-box-binding factor TFIID is implicated.

引用

收藏

页码：83 / 86

页数：4

相关论文

共 15 条

[1] 5 INTERMEDIATE COMPLEXES IN TRANSCRIPTION INITIATION BY RNA POLYMERASE-II [J].

BURATOWSKI, S ;

HAHN, S ;

GUARENTE, L ;

SHARP, PA .

CELL, 1989, 56 (04) :549-561

[2]

DIERICH A, 1989, EMBO J, V8, P2305

[3] UV CROSS-LINKING IDENTIFIES 4 POLYPEPTIDES THAT REQUIRE THE TATA BOX TO BIND TO THE DROSOPHILA-HSP70 PROMOTER [J].

GILMOUR, DS ;

DIETZ, TJ ;

ELGIN, SCR .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (08) :4233-4238

[4] HIGHLY CONSERVED CORE DOMAIN AND UNIQUE N-TERMINUS WITH PRESUMPTIVE REGULATORY MOTIFS IN A HUMAN TATA FACTOR (TFIID) [J].

HOFFMANN, A ;

SINN, E ;

YAMAMOTO, T ;

WANG, J ;

ROY, A ;

HORIKOSHI, M ;

ROEDER, RG .

NATURE, 1990, 346 (6282) :387-390

[5] A TATA BOX IMPLICATED IN E1A TRANSCRIPTIONAL ACTIVATION OF A SIMPLE ADENOVIRUS-2 PROMOTER [J].

LILY, W ;

ROSSER, DSE ;

SCHMIDT, MC ;

BERK, A .

NATURE, 1987, 326 (6112) :512-515

[6]

MATSUI T, 1980, J BIOL CHEM, V255, P1992

[7] FACTORS INVOLVED IN SPECIFIC TRANSCRIPTION BY HUMAN RNA-POLYMERASE .2. ANALYSIS BY A RAPID AND QUANTITATIVE INVITRO ASSAY [J].

SAWADOGO, M ;

ROEDER, RG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (13) :4394-4398

[8] E1A-DEPENDENT TRANSACTIVATION OF THE C-FOS PROMOTER REQUIRES THE TATAA SEQUENCE [J].

SIMON, MC ;

ROONEY, RJ ;

FISCH, TM ;

HEINTZ, N ;

NEVINS, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :513-517

[9] A CONTRIBUTION OF THE CORE-PROMOTER AND ITS SURROUNDING REGIONS TO THE PREFERENTIAL TRANSCRIPTION OF THE FIBROIN GENE IN POSTERIOR SILK GLAND EXTRACTS [J].

TAKIYA, S ;

HUI, CC ;

SUZUKI, Y .

EMBO JOURNAL, 1990, 9 (02) :489-496

[10] CORE PROMOTER OF THE MOUSE MYELIN BASIC-PROTEIN GENE GOVERNS BRAIN-SPECIFIC TRANSCRIPTION INVITRO [J].

TAMURA, T ;

SUMITA, K ;

HIROSE, S ;

MIKOSHIBA, K .

EMBO JOURNAL, 1990, 9 (10) :3101-3108