THE CLASTOGENIC EFFECT OF PYRIMETHAMINE (DARAPRIM) ON HUMAN-CHROMOSOMES IN LYMPHOCYTE-CULTURES

被引：24

作者：

EGELI, U ^{[1
]}

ERDOGAN, G ^{[1
]}

机构：

[1] ISTANBUL UNIV,FAC MED,DEPT INTERNAL MED,MED GENET BRANCH,ISTANBUL,TURKEY

来源：

CELL BIOLOGY AND TOXICOLOGY | 1991年 / 7卷 / 04期

关键词：

PYRIMETHAMINE; CLASTOGENIC EFFECT; FOLIC ACID ANTAGONIST;

D O I：

10.1007/BF00124070

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this study the clastogenic effect of pyrimethamine (Daraprim), a folic acid antagonist used for the treatment of toxoplasmosis and malaria on human chromosomes, was investigated. Pyrimethamine was added to in vitro lymphocyte cultures at six different concentrations: 0.05 (normal therapeutic dose), 0.1, 0.2, 0.4, 0.8, and 1.6 mg/ml. No proliferation was observed in any of the cultures containing 1.6 mg/ml pyrimethamine. The results of the cytogenetic evaluations show that the frequency of breaks and gaps increase significantly in dose-dependent manner. Thus, pyrimethamine has a clastogenic effect on human chromosomes.

引用

页码：347 / 356

页数：10

共 18 条

[1]

CLARKE GM, 1983, BASIC STATISTICS

[2]

DIPELMA J, 1971, DRILLS PHARM MED, P1770

[3]

DYKE VK, 1982, ANTIMALARIAL DRUGS

[4]

GLOVER TW, 1988, AM J HUM GENET, V43, P265

[5] FRAGILE SITES IN CHROMOSOMES - POSSIBLE MODEL FOR THE STUDY OF SPONTANEOUS CHROMOSOME BREAKAGE [J].

JACKY, PB ;

BEEK, B ;

SUTHERLAND, GR .

SCIENCE, 1983, 220 (4592) :69-70

[6]

KRISHASWAMY K, 1980, DRUG TREATMENT PRINC, P1204

[7]

LAURENCE DR, 1980, CLIN PHARM

[8]

MEYERS HF, 1974, REV MED PHARM

[9]

OSOL A, 1973, US DISPENSTORY

[10] FOLIC-ACID AND CHROMOSOME BREAKAGE .1. IMPLICATIONS FOR GENOTOXICITY STUDIES [J].

REIDY, JA ;

ZHOU, XT ;

CHEN, ATL .

MUTATION RESEARCH, 1983, 122 (02) :217-221

← 1 2 →