PROTON NUCLEAR-MAGNETIC-RESONANCE STUDIES ON WATER-STRUCTURE IN PERITUMORAL EDEMATOUS BRAIN-TISSUE

Spin–lattice relaxation times (T1) of water protons and cross‐relaxation times (TIS) between irradiated protein and water protons were measured to study the water structure in peritumoral edematous brain tissue of rats. Despite small changes in T1, water, and electrolyte contents, TIS values of water protons were significantly reduced in peritumoral edematous brain tissue when compared to those of the controls. Results indicate that the water structure in brain tissues may become altered at an early stage of edemic formation without causing any significant changes in cellular hydration. TIS, might serve as a sensitive parameter for studying the water structure in a variety of tissues, such as in edematous brain tissue. © 1992 Academic Press, Inc. Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company