PORE MORPHOLOGY EFFECTS ON THE FIBROVASCULAR TISSUE-GROWTH IN POROUS POLYMER SUBSTRATES

被引：236

作者：

WAKE, MC

PATRICK, CW

MIKOS, AG

机构：

[1] RICE UNIV,DEPT CHEM ENGN,HOUSTON,TX 77251

[2] RICE UNIV,INST BIOSCI & BIOENGN,COX LAB BIOMED ENGN,HOUSTON,TX 77251

来源：

CELL TRANSPLANTATION | 1994年 / 3卷 / 04期

关键词：

PREVASCULARIZATION; BIODEGRADABLE POLYMER SCAFFOLDS; ORGAN REGENERATION; TISSUE REGENERATION;

D O I：

10.1177/096368979400300411

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The feasibility of developing biodegradable polymer scaffolds to engineer tissues was investigated by studying the effects of pore size on the dynamics of fibrovascular tissue ingrowth. Tissue advanced into amorphous poly(L-lactic acid) porous substrates faster as the pore diameter increased. Porous cylindrical devices of 13.5 mm diameter, 5 mm thickness, and approximately 500 mu m pore size were filled completely by tissue 5 days postimplantation. Although prevascularized devices possessed minimal void volume for cell seeding to regenerate metabolic organs, they hold promise in the regeneration of tubular tissues by relying on the epithelization of prevascularized grafts.

引用

页码：339 / 343

页数：5

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