AMANTADINE DOES NOT REDUCE COCAINE USE OR CRAVING IN COCAINE-DEPENDENT METHADONE-MAINTENANCE PATIENTS

被引：28

作者：

HANDELSMAN, L

LIMPITLAW, L

WILLIAMS, D

SCHMEIDLER, J

PARIS, P

STIMMEL, B

机构：

[1] MT SINAI MED CTR,DEPT PSYCHIAT,NEW YORK,NY 10029

[2] MT SINAI MED CTR,DEPT MED,NEW YORK,NY 10029

[3] MT SINAI MED CTR,CTR NARCOT REHABIL,NEW YORK,NY 10029

来源：

DRUG AND ALCOHOL DEPENDENCE | 1995年 / 39卷 / 03期

关键词：

COCAINE DEPENDENCE; METHADONE MAINTENANCE; AMANTADINE; DOPAMINE AGONIST; CLINICAL TRIAL;

D O I：

10.1016/0376-8716(95)01154-9

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

We tested the efficacy of amantadine to reduce cocaine use or craving in cocaine-dependent methadone maintained patients. Two doses of amantadine (200 mg p.o. daily, n = 16, and 200 mg p.o. bid, n = 21) were tested against placebo, n = 22, in a random assignment, double-blind clinical trial lasting nine weeks. Amantadine was well tolerated. However, neither dose of amantadine was more effective than placebo in reducing cocaine use and craving.

引用

页码：173 / 180

页数：8

共 22 条

[1] AMANTADINE MAY FACILITATE DETOXIFICATION OF COCAINE ADDICTS [J].