CLOZAPINE INCREASES BREAKING POINTS ON A PROGRESSIVE-RATIO SCHEDULE REINFORCED BY INTRAVENOUS COCAINE

被引：39

作者：

LOH, EA ^{[1
]}

FITCH, T ^{[1
]}

VICKERS, G ^{[1
]}

ROBERTS, DCS ^{[1
]}

机构：

[1] CARLETON UNIV, DEPT PSYCHOL, OTTAWA K1S 5B6, ONTARIO, CANADA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 42卷 / 03期

关键词：

SELF-ADMINISTRATION; COCAINE; CLOZAPINE; DOPAMINE; SEROTONIN; PROGRESSIVE RATIO; ATYPICAL NEUROLEPTIC;

D O I：

10.1016/0091-3057(92)90156-A

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effect of the atypical neuroleptic clozapine on cocaine self-administration reinforced on a progressive-ratio schedule in rats was examined. The rat's first response on a lever each day produced an IV infusion of cocaine (0.6 mg/injection) after which the requirements of the schedule escalated with each infusion until the frequency of responding on the lever fell below a criterion level. The final ratio completed was defined as the breaking point. Doses of 5 and 20 mg/kg clozapine produced either no effect or a nonspecific disruption in responding. Rats pretreated with 10 mg/kg clozapine responded to significantly higher breaking points, indicating an increased motivation to self-administer cocaine.

引用

页码：559 / 562

页数：4

共 25 条

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