METABOLIC ENGINEERING - METHODOLOGIES AND FUTURE-PROSPECTS

被引：84

作者：

STEPHANOPOULOS, G ^{[1
]}

SINSKEY, AJ ^{[1
]}

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

TRENDS IN BIOTECHNOLOGY | 1993年 / 11卷 / 09期

关键词：

D O I：

10.1016/0167-7799(93)90099-U

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Attempts to improve the productivity of cellular systems or to increase metabolite yield often require radical alteration of the flux through primary metabolic pathways. However, achieving the desired result often proves difficult because the control architectures at key branch points have evolved to resist flux changes. Identification and characterization of these metabolic nodes is a prerequisite to rational metabolic engineering.

引用

页码：392 / 396

页数：5

共 21 条

[1] GENETIC-ENGINEERING OF METABOLIC PATHWAYS APPLIED TO THE PRODUCTION OF PHENYLALANINE [J].