SYNTHESIS OF RACEMIC 3-METHYLPHOSPHONATE ANALOGS OF MYOINOSITOL 3,4-BISPHOSPHATE AND 1,3,4-TRISPHOSPHATE

被引：31

作者：

DREEF, CE

TUINMAN, RJ

LEFEBER, AWM

ELLE, CJJ

VANDERMAREL, GA

VANBOOM, JH

机构：

[1] Gorlaeus Laboratories, 2300 RA Leiden

来源：

TETRAHEDRON | 1991年 / 47卷 / 26期

关键词：

D O I：

10.1016/S0040-4020(01)86476-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The partially benzyl protected myo-inositol derivatives 11a and 11b, the C-4 and C-1,4 hydroxyl function(s) of which are protected with temporary trans-prop-1-enyl protecting group(s), were readily converted into the respective title compounds 18a and 18b by sequential methylphosphonylation, mild cleavage of the trans-prop-1-enyl group(s), phosphorylation and removal of all permanent benzyl protecting groups.

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页码：4709 / 4722

页数：14

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