BRADYKININ STIMULATES PROSTAGLANDIN-E2 FORMATION IN ISOLATED HUMAN OSTEOBLAST-LIKE CELLS

被引：15

作者：

LJUNGGREN, O ^{[1
]}

ROSENQUIST, J ^{[1
]}

RANSJO, M ^{[1
]}

LERNER, UH ^{[1
]}

机构：

[1] UMEA UNIV,DEPT ORAL SURG,S-90187 UMEA,SWEDEN

来源：

BIOSCIENCE REPORTS | 1990年 / 10卷 / 01期

关键词：

Bradykinin; osteoblasts; prostaglandin E[!sub]2[!/sub;

D O I：

10.1007/BF01116860

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of bradykinin on prostaglandin E2 formation in cells from human trabecular bone has been studied. The cells responded to parathyroid hormone with enhanced cyclic AMP formation and were growing as cuboidal-shaped, osteoblast-like cells. In these isolated human osteoblast-like cells, bradykinin (1 μmol/l) caused a rapid (5 min) stimulation of prostaglandin E2 formation. This finding indicates that human osteoblasts are equipped with receptors for bradykinin linked to an increase in prostaglandin formation. © 1990 Plenum Publishing Corporation.

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页码：121 / 126

页数：6

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