CORTICAL SEROTONIN RECEPTOR SUBTYPES AFTER LESION OF ASCENDING CHOLINERGIC NEURONS IN RAT

被引:16
作者
CROSS, AJ [1 ]
DEAKIN, JFW [1 ]
机构
[1] UNIV MANCHESTER, DEPT PSYCHIAT, MANCHESTER M13 9PL, LANCS, ENGLAND
关键词
D O I
10.1016/0304-3940(85)90587-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Serotonin (5-HT) S1 and S2 receptors were studied in rat cortex after lesion of the ascending cholinergic systems by injection of ibotenic acid into the nucleus basalis. The lesions produced a large (56%) decrease in choline acetyltransferase activity with no change in markers of .gamma.-aminobutyric acid, dopamine and 5-HT containing neurones. Lesions of the ascending cholinergic neurones were accompanied by a loss of 5-HT S1 receptor binding sites with no change in S2 receptors. These results suggest that a proportion of S1 receptors may be associated with cholinergic terminals.
引用
收藏
页码:261 / 265
页数:5
相关论文
共 20 条