A METHOD TO PREDICT THE PERCUTANEOUS PERMEABILITY OF VARIOUS COMPOUNDS - SHED SNAKE SKIN AS A MODEL MEMBRANE

被引：28

作者：

ITOH, T ^{[1
]}

MAGAVI, R ^{[1
]}

CASADY, RL ^{[1
]}

NISHIHATA, T ^{[1
]}

RYTTING, JH ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT PHARMACEUT CHEM,LAWRENCE,KS 66045

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 12期

关键词：

black rat snake; distribution coefficient; Elaphe obsoleta; molecular weight; permeability; shed snake skin; skin penetration;

D O I：

10.1023/A:1015902308676

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Penetration of various compounds through shed snake skin was measured in vitro to examine the effect of lipophilicity and molecular size of a compound on permeability through this model membrane. The permeabilities were found to be controlled by the lipophilicity and the molecular size of the permeant. The smaller and the more lipophilic the compound, the greater the permeability. Equations have been developed to predict the permeability from the molecular weight and the distribution coefficient of a compound. Further, the lipophilicity of shed snake skin is similar to that of human skin and the response of shed snake skin to the molecular size of a permeant is more similar to human skin than to hairless mouse skin. Considering the similarities between shed snake skin and human stratum coraeum in terms of structure, composition, and permeability characteristics, the same considerations may apply to permeability through human stratum corneum. © 1990, Plenum Publishing Corporation. All rights reserved.

引用

页码：1302 / 1306

页数：5

共 11 条

[1] AN AUTOMATED-METHOD FOR CONTINUOUSLY MONITORING DIFFUSION CELLS IN SKIN PENETRATION STUDIES [J].