BLOCKADE OF INTERLEUKIN-1 INDUCED HYPERTHERMIA BY SUBDIAPHRAGMATIC VAGOTOMY - EVIDENCE FOR VAGAL MEDIATION OF IMMUNE BRAIN COMMUNICATION

被引：385

作者：

WATKINS, LR ^{[1
]}

GOEHLER, LE ^{[1
]}

RELTON, JK ^{[1
]}

TARTAGLIA, N ^{[1
]}

SILBERT, L ^{[1
]}

MARTIN, D ^{[1
]}

MAIER, SF ^{[1
]}

机构：

[1] SYNERGEN INC,BOULDER,CO 80301

来源：

NEUROSCIENCE LETTERS | 1995年 / 183卷 / 1-2期

关键词：

INTERLEUKIN-1-BETA; HYPERTHERMIA; RAT; TELEMETRY; ILLNESS; STRESS HYPERTHERMIA; CYTOKINE;

D O I：

10.1016/0304-3940(94)11105-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin-1 beta (IL-1 beta), a cytokine released by activated immune cells, elicits various illness symptoms including hyperthermia. Previous hypotheses to account for these actions have focused on blood-borne IL-1 beta exerting its effects directly at the level of the brain. However, recent behavioral and physiological evidence suggest that IL-1 beta can activate the subdiaphragmatic vagus. The present experiments demonstrate that subdiaphragmatic vagal transection disrupts the hyperthermia-inducing effects of recombinant human IL-1 beta and stress. These data provide evidence for a novel route of immune-brain communication, as well as a novel route whereby stress can influence physiological processes.

引用

页码：27 / 31

页数：5

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