ANTITUMOR-ACTIVE HETEROGLYCANS FROM NIOHSHIMEJI MUSHROOM, TRICHOLOMA-GIGANTEUM

被引:22
作者
MIZUNO, T
KINOSHITA, T
ZHUANG, C
ITO, H
MAYUZUMI, Y
机构
[1] GIFU UNIV, SHIZUOKA UNIV, UNITED GRAD SCH AGR SCI, GIFU 50111, JAPAN
[2] MIE UNIV, SCH MED, DEPT PHARMACOL, TSU, MIE 514, JAPAN
[3] MYOGI MUSHROOM DEV FARM, MATUSIDA, GUNMA 37902, JAPAN
关键词
D O I
10.1271/bbb.59.568
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Water-soluble polysaccharide FI and water-insoluble polysaccharides FII, FIII-1, and FIII-2 were obtained from fruiting bodies of Tricholoma giganteum. Polysaccharides were further fractionated by ion-exchange chromatography, gel filtration, and affinity chromatography. The 24 polysaccharide fractions obtained were examined for their antitumor effect on Sarcoma 180 implanted in mice, The following antitumor-active polysaccharides were identified: FIo-a, a mixture of alpha-D-glucan and xyloglucomannan with an average molecular weight of 1.6 x 10(6); FA-1, a beta-D-glucan containing 1% protein and with a molecular weight of 4.0 x 10(4); FLI-1, a (1-->3)-beta-D-glucan containing 7.8% protein, with a molecular weight of 5.2 x 10(4); FIII-1-b, a protein-polysaccharide complex (ratio, 37.5:62.5, w/w), with a molecular weight of 6.8 x 10(4) and with xylose, galactose, mannose, and glucose in the polysaccharide moiety (proportions of 8.9:14.9:29.3:46.9 by weight), and FIII-2-a, b, and c, three (1-->6)-beta-D-glucosyl-branched (1-->3)-beta-D-glucans with a molecular weight from 2.6 x 10(5) to 4.1 x 10(5) and containing small amounts of xylose and galactose and 3.5-8.3% protein.
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收藏
页码:568 / 571
页数:4
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