PLASMA-LEVELS OF THE PRODRUG, ARBAPROSTIL, [(15R)-15-METHYLPROSTAGLANDIN E2], AND ITS ACTIVE, ANTIULCER (15S) EPIMER IN HUMANS AFTER SINGLE DOSE ORAL-ADMINISTRATION

被引：9

作者：

COX, JW

BOTHWELL, WM

PULLEN, RH

WYNALDA, MA

FITZPATRICK, FA

VANDERLUGT, JT

机构：

[1] UPJOHN CO,LIPID RES,KALAMAZOO,MI 49001

[2] UPJOHN CO,DIV PHARMACEUT RES & DEV,KALAMAZOO CLIN INVEST COMPLEX,KALAMAZOO,MI 49001

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1986年 / 75卷 / 11期

关键词：

D O I：

10.1002/jps.2600751118

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1107 / 1112

页数：6

共 26 条

[1]

COX J, UNPUB

[2]

COX JW, 1985, ANAL CHEM, V57, P2366

[3]

COX JW, 1984, ANAL CHEM, V56, P2365

[4]

DRAY F, 1982, METHOD ENZYMOL, V86, P258

[5] HAPTEN MIMIC ELICITS ANTIBODIES RECOGNIZING PROSTAGLANDIN-E2 [J].

FITZPATRICK, FA ;

BUNDY, GL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (06) :2689-2693

[6] ALBUMIN-LIPID INTERACTIONS - PROSTAGLANDIN STABILITY AS A PROBE FOR CHARACTERIZING BINDING-SITES ON VERTEBRATE ALBUMINS [J].

FITZPATRICK, FA ;

WYNALDA, MA .

BIOCHEMISTRY, 1981, 20 (21) :6129-6134

[7]

FITZPATRICK FA, 1984, J BIOL CHEM, V259, P2722

[8] EFFECT OF 15 (R) 15 METHYL PROSTAGLANDIN-E2 ON HEALING OF GASTRIC-ULCERS - DOUBLE-BLIND ENDOSCOPIC STUDY [J].

FUNG, WP ;

KARIM, SMM .

MEDICAL JOURNAL OF AUSTRALIA, 1976, 2 (04) :127-128

[9]

GILBERT DA, 1984, GASTROENTEROLOGY, V86, P338

[10] GASTROINTESTINAL PROTECTION BY LOW-DOSE ORAL PROSTAGLANDIN-E2 IN RHEUMATIC DISEASES [J].

KOLLBERG, B ;

NORDEMAR, R ;

JOHANSSON, C .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1981, 16 (08) :1005-1008

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