OXYGENATED CHOLESTEROLS AS LIGANDS FOR CYTOSOLIC-NUCLEAR TUMOR PROMOTER-BINDING PROTEIN - YAKKASTEROIDS

被引：13

作者：

ENDO, Y

HASHIMOTO, Y

FUKASAWA, H

SHUDO, K

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN

[2] UNIV TOKYO,INST MOLEC & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 194卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1998

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several oxygenated cholesterols and their derivatives (yakkasteroids) were prepared as candidate ligands for cytosolic-nuclear tumor promoter binding protein (CN-TPBP). Among the compounds, a possible natural substance, 3β,5α-dihydroxycholestan-6-one (yakkasterone), showed the highest binding affinity to CN-TPBP. It also showed high specificity for binding to CN-TPBP: it does not bind to protein kinase C. Investigation of the structure-activity relationships of yakkasteroids revealed that the structure of the side chain at the 20-position is important for the binding activity to CN-TPBP. © 1993 Academic Press, Inc.

引用

页码：1529 / 1535

页数：7

共 14 条

[1]

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[2]

BLUMBERG PM, 1981, CRC CRIT R TOXICOL, V9, P153

[3] SYNTHESIS OF 7-SUBSTITUTED INDOLACTAM .5. AN INTRODUCTION OF HYDROPHOBIC MOIETIES ON THE INDOLE RING [J].