N-MANNICH BASE DERIVATIVES OF 5-FLUOROCYTOSINE - A PRODRUG APPROACH TO IMPROVE TOPICAL DELIVERY

被引：11

作者：

KOCH, SAM ^{[1
]}

SLOAN, KB ^{[1
]}

机构：

[1] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL PHARM,BOX J485,GAINESVILLE,FL 32610

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1987年 / 35卷 / 03期

关键词：

D O I：

10.1016/0378-5173(87)90136-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：243 / 252

页数：10

共 25 条

[1]

BODOR N, 1983, INT J PHARM, V15, P233

[2] PRODRUGS AS DRUG DELIVERY SYSTEMS .4. N-MANNICH BASES AS POTENTIAL NOVEL PRODRUGS FOR AMIDES, UREIDES, AMINES, AND OTHER NH-ACIDIC COMPOUNDS [J].

BUNDGAARD, H ;

JOHANSEN, M .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1980, 69 (01) :44-46

[3] EVIDENCE FOR CONVERSION OF 5-FLUOROCYTOSINE TO 5-FLUOROURACIL IN HUMANS - POSSIBLE FACTOR IN 5-FLUOROCYTOSINE CLINICAL TOXICITY [J].

DIASIO, RB ;

LAKINGS, DE ;

BENNETT, JE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1978, 14 (06) :903-908

[4] THE COSMETIC INGREDIENT REVIEW - A SAFETY EVALUATION PROGRAM [J].

ELDER, RL .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1984, 11 (06) :1168-1174

[5]

FROSCH PJ, 1977, CUTANEOUS TOXICITY, P127

[6]

GRINGAUZ A, 1983, PHARM TIMES, P70

[7] N-SULFOMETHYLATION OF GUANINE, ADENINE AND CYTOSINE WITH FORMALDEHYDE-BISULFITE - A SELECTIVE MODIFICATION OF GUANINE IN DNA [J].

HAYATSU, H ;

YAMASHITA, Y ;

YUI, S ;

YAMAGATA, Y ;

TOMITA, KI ;

NEGISHI, K .

NUCLEIC ACIDS RESEARCH, 1982, 10 (20) :6281-6293

[8]

JENCKS WP, 1969, CATALYSIS CHEM ENZYM, P562

[9] CHARACTERIZATION OF NX,NY-DISUBSTITUTED ADENINES BY ULTRAVIOLET ABSORPTION SPECTRA [J].

LEONARD, NJ ;

CARRAWAY, KL ;

HELGESON, JP .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (03) :291-&

[10]

MARTIN A, 1983, PHYSICAL PHARM, P299

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