RADIOBIOLOGY OF ALPHA-PARTICLES .4. CELL INACTIVATION BY ALPHA-PARTICLES OF ENERGIES 0.4-3.5 MEV

被引：36

作者：

RAJU, MR

EISEN, Y

CARPENTER, S

JARRETT, K

HARVEY, WF

机构：

[1] Soreq Nuclear Research Center

来源：

RADIATION RESEARCH | 1993年 / 133卷 / 03期

关键词：

D O I：

10.2307/3578212

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this report the effectiveness of low-energy α particles in the range 0.4 to 3.5 MeV for cell killing is investigated. Four cell lines of different nuclear dimensions (AG1522, C3H 10T1/2, CHO-10B, and HS-23) are studied. Monte Carlo simulations are carried out to interpret the experimental results. They are presented as a function of dose to the nucleus, the total track length of α particles in the nucleus, and other parameters. It is found that the effectiveness of α particles for cell killing decreases with decreasing α-particle energy. The maximum RBE value is found to extend to LET values as high as 180 keV/μm. Although the LET might be the same, the effectiveness of α particles for cell killing is higher in the ascending part of the Bragg curve compared to descending part of the Bragg curve. The terminal tracks of α particles are observed to be less effective for cell killing.

引用

收藏

页码：289 / 296

页数：8

相关论文

共 15 条

[1] EFFECTS OF DIFFERENT IONIZING RADIATIONS ON HUMAN CELLS IN TISSUE CULTURE .3. EXPERIMENTS WITH CYCLOTRON-ACCELERATED ALPHA-PARTICLES AND DEUTERONS [J].

BARENDSEN, GW ;

WALTER, HMD ;

BEWLEY, DK ;

FOWLER, JF .

RADIATION RESEARCH, 1963, 18 (01) :106-&

[2] IMPAIRMENT OF THE PROLIFERATIVE CAPACITY OF HUMAN CELLS IN CULTURE BY ALPHA-PARTICLES WITH DIFFERING LINEAR-ENERGY TRANSFER [J].

BARENDSEN, GW .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE, 1964, 8 (05) :453-466

[3] RADIOBIOLOGY OF ULTRASOFT X-RAYS .4. FLAT AND ROUND-SHAPED HAMSTER-CELLS (CHO-10B, HS-23) [J].

CARPENTER, S ;

CORNFORTH, MN ;

HARVEY, WF ;

RAJU, MR ;

SCHILLACI, ME ;

WILDER, ME ;

GOODHEAD, DT .

RADIATION RESEARCH, 1989, 119 (03) :523-533

[4]

Cole A, 1980, RAD BIOL CANCER RES, P33

[5] RADIOBIOLOGY OF ULTRASOFT X-RAYS .3. NORMAL HUMAN-FIBROBLASTS AND THE SIGNIFICANCE OF TERMINAL TRACK STRUCTURE IN CELL INACTIVATION [J].

CORNFORTH, MN ;

SCHILLACI, ME ;

GOODHEAD, DT ;

CARPENTER, SG ;

WILDER, ME ;

SEBRING, RJ ;

RAJU, MR .

RADIATION RESEARCH, 1989, 119 (03) :511-522

[6] USE OF TRACK-END ALPHA-PARTICLES FROM AM-241 TO STUDY RADIOSENSITIVE SITES IN CHO CELLS [J].

DATTA, R ;

COLE, A ;

ROBINSON, S .

RADIATION RESEARCH, 1976, 65 (01) :139-151

[7] RADIOBIOLOGY OF ALPHA-PARTICLES .2. DOSIMETRY OF LOW-ENERGY ALPHA-PARTICLES USING PARALLEL-PLATE IONIZATION CHAMBERS AND A SURFACE-BARRIER DETECTOR [J].

EISEN, Y ;

HARVEY, WF ;

RAJU, MR .

RADIATION RESEARCH, 1991, 128 (02) :197-203

[8] RADIOBIOLOGY OF ALPHA-PARTICLES .1. EXPOSURE SYSTEM AND DOSIMETRY [J].

INKRET, WC ;

EISEN, Y ;

HARVEY, WF ;

KOEHLER, AM ;

RAJU, MR .

RADIATION RESEARCH, 1990, 123 (03) :304-310

[9]

JAMES AC, 1991, RADIAT PROT DOSIM, V37, P221

[10] RADIOBIOLOGY OF ULTRASOFT X-RAYS .1. CULTURED HAMSTER-CELLS (V79) [J].

RAJU, MR ;

CARPENTER, SG ;

CHMIELEWSKI, JJ ;

SCHILLACI, ME ;

WILDER, ME ;

FREYER, JP ;

JOHNSON, NF ;

SCHOR, PL ;

SEBRING, RJ ;

GOODHEAD, DT .

RADIATION RESEARCH, 1987, 110 (03) :396-412