ADRENIC ACID DELTA-4 DESATURATION AND FATTY-ACID COMPOSITION IN LIVER-MICROSOMES OF SPONTANEOUSLY DIABETIC WISTAR BB RATS

被引：8

作者：

MIMOUNI, V

NARCE, M

HUANG, YS

HORROBIN, DF

POISSON, JP

机构：

[1] UNIV BOURGOGNE,FAC SCI MIRANDE,UNITE RECH NUTR CELLULAIRE & METAB,F-21004 DIJON,FRANCE

[2] UNIV TOULON & VAR,F-83957 LA GARDE,FRANCE

[3] EFAMOL RES INST,KENTVILLE B4N 4H8,NS,CANADA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1994年 / 50卷 / 01期

关键词：

D O I：

10.1016/0952-3278(94)90104-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the Delta 4 (n-6) desaturation and the fatty acid composition of liver microsomes in the insulin-dependent spontaneously diabetic Wistar Bio-Breeding (BB) rat. The desaturation of adrenic acid to n-6 docosapentaenoic acid was decreased in the normo- and hyperglycemic diabetic rats. Insulin treatment with 1.0 IU. 100 g body weight(-1) twice a day for 2 days restored the reduced activity during the hypoglycemic period. The pattern of responses was similar to that of linoleic acid Delta 6 and dihomo-gamma-linolenic acid Delta 5 desaturases, with a non-parallel relationship between the desaturation system and the glycemia. The microsomal fatty acid composition of BB rat liver reflected only partially to the Delta 4 desaturation at different states of glycemia. Factors other than impaired desaturation system are involved in the fatty acid metabolism of spontaneously diabetic rats.

引用

页码：43 / 47

页数：5

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