IMPROVEMENT OF LIVER FIBROSIS IN CHRONIC HEPATITIS-C PATIENTS TREATED WITH NATURAL INTERFERON-ALPHA

被引：108

作者：

HIRAMATSU, N ^{[1
]}

HAYASHI, N ^{[1
]}

KASAHARA, A ^{[1
]}

HAGIWARA, H ^{[1
]}

TAKEHARA, T ^{[1
]}

HARUNA, Y ^{[1
]}

NAITO, M ^{[1
]}

FUSAMOTO, H ^{[1
]}

KAMADA, T ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT MED 1,SUITA,OSAKA 565,JAPAN

来源：

JOURNAL OF HEPATOLOGY | 1995年 / 22卷 / 02期

关键词：

HEPATIC FIBROSIS SCORE; HEPATITIS C VIRUS; LIVER FIBROSIS; PROCOLLAGEN TYPE III PEPTIDE; TYPE IV COLLAGEN-7S;

D O I：

10.1016/0168-8278(95)80420-X

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

To investigate the histological change (change of liver fibrosis) produced by the anti-viral effect of interferon on hepatitis C virus, 40 patients with chronic hepatitis C treated with natural interferon alpha were divided according to the existence of viremia at the end of treatment and 6 months after the end of treatment. The condition of liver fibrosis was scored numerically with a new ''hepatic fibrosis score'' which is sensitive to more subtle changes than Knodell's fibrosis score. Each portal zone was evaluated separately. End-of-treatment biopsy for the HCV RNA-negative group (negative for HCV RNA at the end of treatment) showed a significant improvement of the ''hepatic fibrosis score'' as well as the alleviation of necrosis and inflammation. At the end of treatment and 6 months after that, serum procollagen type III: peptide levels and serum type IV collagen-7s levels had also decreased significantly in the HCV RNA-negative group. The present study showed that treatment with interferon alpha could alleviate fibrosis in addition to necrosis and inflammation.

引用

页码：135 / 142

页数：8

共 35 条

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