CORTISOL PRODUCTION-RATE IN CHILDHOOD AND ADOLESCENCE

被引：145

作者：

LINDER, BL

ESTEBAN, NV

YERGEY, AL

WINTERER, JC

LORIAUX, DL

CASSORLA, F

机构：

[1] NICHHD, DEV ENDOCRINOL BRANCH, BETHESDA, MD 20892 USA

[2] NICHHD, THEORET & PHYS BIOL LAB, BETHESDA, MD 20892 USA

来源：

JOURNAL OF PEDIATRICS | 1990年 / 117卷 / 06期

关键词：

D O I：

10.1016/S0022-3476(05)80128-3

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We studied the daily cortisol production rate in 33 normal children and adolescents, using a stable isotope-dilution technique employing high-performance liquid chromatography-mass spectrometry. Two indwelling intravenous catheters were inserted and tracer 9,12,12-2H3-cortisol (deuterated cortisol) was infused continuously for 30 hours. After 6 hours of tracer infusion to allow for equilibration, blood was obtained every 20 minutes for 24 hours. The mean (±SD) cortisol production rate was 9.5±2.5 mg/day (6.8±1.9 mg/m2/day). Cortisol production rate did not vary with sex or pubertal stage. These results suggest that the cortisol production rate in children and adolescents is significantly lower than previously estimated. © 1990 Mosby-Year Book, Inc.

引用

页码：892 / 896

页数：5

共 18 条

[1]

BJORKHEM I, 1981, CLIN CHEM, V27, P733

[2]

COPE CL, 1958, CLIN SCI, V17, P147

[3] STABLE ISOTOPE-DILUTION METHOD USING THERMOSPRAY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY FOR QUANTIFICATION OF DAILY CORTISOL PRODUCTION IN HUMANS [J].