METHIONINE-ENKEPHALIN IN MIGRAINE AND TENSION HEADACHE - DIFFERENCES BETWEEN CLASSIC MIGRAINE, COMMON MIGRAINE AND TENSION HEADACHE, AND CHANGES DURING ATTACKS

被引：16

作者：

FERRARI, MD

ODINK, J

FROLICH, M

PORTIELJE, JEA

BRUYN, GW

机构：

[1] UNIV HOSP LEIDEN,DEPT CHEM PATHOL,2300 RC LEIDEN,NETHERLANDS

[2] TNO,CIVO TOXICOL & NUTR INST,DEPT CLIN BIOCHEM,ZEIST,NETHERLANDS

来源：

HEADACHE | 1990年 / 30卷 / 03期

关键词：

D O I：

10.1111/j.1526-4610.1990.hed3003160.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

SYNOPSIS We measured methionine‐enkephalin (MET) in platelets and platelet‐poor‐plasma of drug‐free patients with classic migraine, common migraine or tension headache (TH). Migraineurs were studied both between and during attacks. TH patients were characterized by low platelet‐MET and high plasma‐MET levels, whereas migraine patients showed high platelet‐MET and reduced plasma‐MET levels. During migraine attacks both platelet and plasma‐MET concentrations increased considerably. We suggest that determination of MET levels in platelets and plasma may be a useful marker to discriminate between TH and common migraine. The rise in MET during attacks may be directed against the ictal increase of serotonin. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：160 / 164

页数：5

共 35 条

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