REGIONAL CHANGES OF TISSUE PH AND ATP CONTENT IN RAT-BRAIN FOLLOWING SYSTEMIC ADMINISTRATION OF KAINIC ACID

被引：13

作者：

KOBAYASHI, S ^{[1
]}

KIKUCHI, H ^{[1
]}

ISHIKAWA, M ^{[1
]}

HASHIMOTO, K ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT NEUROSURG,KYOTO 606,JAPAN

来源：

BRAIN RESEARCH | 1990年 / 514卷 / 02期

关键词：

Acidosis; Adenosine triphosphate; Dendrite; Hippocampus; Kainic acid; Limbic structure; Soma;

D O I：

10.1016/0006-8993(90)91432-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regional metabolic alterations induced by systemic administration of kainic acid were investigated in rat brains. The histochemical study revealed that an acidic pH shift preceded an ATP decrease in the limbic structures. In the hippocampal Ammon's horn, it was noted that a selective decrease of ATP occured in the dendritic subfield, such as the stratum radiatum and/or the stratum oriens. It was suggested that this selective ATP decrease in the dendrite is directly related to kainate neurotoxicity. © 1990.

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页码：352 / 354

页数：3

相关论文

共 21 条

[1] ELECTROGRAPHIC, CLINICAL AND PATHOLOGICAL ALTERATIONS FOLLOWING SYSTEMIC ADMINISTRATION OF KAINIC ACID, BICUCULLINE OR PENTETRAZOLE - METABOLIC MAPPING USING THE DEOXYGLUCOSE METHOD WITH SPECIAL REFERENCE TO THE PATHOLOGY OF EPILEPSY [J].

BENARI, Y ;

TREMBLAY, E ;

RICHE, D ;

GHILINI, G ;

NAQUET, R .

NEUROSCIENCE, 1981, 6 (07) :1361-1391

[2] CEREBRAL PO2, PCO2 AND PH - CHANGES DURING CONVULSIVE ACTIVITY AND THEIR SIGNIFICANCE FOR SPONTANEOUS ARREST OF SEIZURES [J].

CASPERS, H ;

SPECKMANN, EJ .

EPILEPSIA, 1972, 13 (05) :699-+

[3] SELECTIVE VULNERABILITY OF BRAIN - NEW INSIGHTS FROM THE EXCITATORY SYNAPSE [J].

COLLINS, RC .

METABOLIC BRAIN DISEASE, 1986, 1 (04) :231-240

[4]

COYLE JT, 1983, J NEUROCHEM, V41, P1

[5] INSITU INJECTION OF KAINIC ACID - NEW METHOD FOR SELECTIVELY LESIONING NEURONAL CELL BODIES WHILE SPARING AXONS OF PASSAGE [J].

COYLE, JT ;

MOLLIVER, ME ;

KUHAR, MJ .

JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 180 (02) :301-323

[6] A TOPOGRAPHIC QUANTITATIVE METHOD FOR MEASURING BRAIN-TISSUE PH UNDER PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL CONDITIONS [J].

CSIBA, L ;

PASCHEN, W ;

HOSSMANN, KA .

BRAIN RESEARCH, 1983, 289 (1-2) :334-337

[7] KAINIC ACID SEIZURES AND THE REVERSIBILITY OF CALCIUM LOADING IN VULNERABLE NEURONS IN THE HIPPOCAMPUS [J].

EVANS, MC ;

GRIFFITHS, T ;

MELDRUM, BS .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1984, 10 (04) :285-302

[8] REGIONAL BRAIN GLUCOSE-METABOLISM IN CHEMICALLY-INDUCED SEIZURES IN THE RAT [J].

EVANS, MC ;

MELDRUM, BS .

BRAIN RESEARCH, 1984, 297 (02) :235-245

[9] INFLUENCE OF INVITRO LACTIC-ACIDOSIS AND HYPERCAPNIA ON RESPIRATORY ACTIVITY OF ISOLATED RAT-BRAIN MITOCHONDRIA [J].

HILLERED, L ;

ERNSTER, L ;

SIESJO, BK .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1984, 4 (03) :430-437

[10] ISCHEMIC CA-1 PYRAMIDAL CELL LOSS IS PREVENTED BY PREISCHEMIC COLCHICINE DESTRUCTION OF DENTATE GYRUS GRANULE CELLS [J].

JOHANSEN, FF ;

JORGENSEN, MB ;

DIEMER, NH .

BRAIN RESEARCH, 1986, 377 (02) :344-347