SELECTIVE ADENYLATE-CYCLASE INCREASE IN THE LIMBIC AREA OF LONG-TERM IMIPRAMINE-TREATED RATS

被引：27

作者：

DEMONTIS, GM ^{[1
]}

DEVOTO, P ^{[1
]}

GESSA, GL ^{[1
]}

PORCELLA, A ^{[1
]}

SERRA, G ^{[1
]}

TAGLIAMONTE, A ^{[1
]}

机构：

[1] UNIV CAGLIARI,DEPT NEUROSCI,I-09100 CAGLIARI,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 180卷 / 01期

关键词：

Adenylate cyclase; Antidepressants; α-Methyl-p-tyrosine;

D O I：

10.1016/0014-2999(90)90605-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Long-term administration of imipramine to rats produced an increase in the Vmax of forskolin- or guanylylimido-diphosphate (Gpp(NH))p-activated adenylate cyclase only in the limbic area. This effect was prevented by the daily administration of α-methyl-p-tyrosine (α-MPT), given together with imipramine, at a dose (50 mg/kg) which had no effect on adenylate cyclase activity per se. The time course of the effects of chronic imipramine on dopaminergic transmission in the limbic area showed that the decrease in both D-1 receptor number and adenylate cyclase stimulation by dopamine (DA) reached significance on day 8 of treatment and were maximal on day. The Vmax of the enzyme started to increase on day 15 and was further increased on day 21. Possible mechanisms underlying these effects are discussed. © 1990.

引用

页码：169 / 174

页数：6

共 15 条

[1] BERGSTROM DA, 1979, J PHARMACOL EXP THER, V209, P256
[2] CHARACTERIZATION OF THE BINDING OF H-3-SCH 23390, A SELECTIVE D-1 RECEPTOR ANTAGONIST LIGAND, IN RAT STRIATUM
BILLARD, W
RUPERTO, V
CROSBY, G
IORIO, LC
BARNETT, A
[J]. LIFE SCIENCES, 1984, 35 (18) : 1885 - 1893
[3] MECHANISM OF ADENYLATE-CYCLASE ACTIVATION THROUGH BETA-ADRENERGIC-RECEPTOR - CATECHOLAMINE-INDUCED DISPLACEMENT OF BOUND GDP BY GTP
CASSEL, D
SELINGER, Z
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (09) : 4155 - 4159
[4] CHRONIC IMIPRAMINE REDUCES [H-3] SCH-23390 BINDING AND DA-SENSITIVE ADENYLATE-CYCLASE IN THE LIMBIC SYSTEM
DEMONTIS, GM
DEVOTO, P
GESSA, GL
MELONI, D
PORCELLA, A
SABA, P
SERRA, G
TAGLIAMONTE, A
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 167 (02) : 299 - 303
[5] MULTIPLE RECEPTORS FOR DOPAMINE
KEBABIAN, JW
CALNE, DB
[J]. NATURE, 1979, 277 (5692) : 93 - 96
[6] CHRONIC TREATMENT WITH ANTIDEPRESSANTS DECREASES THE NUMBER OF [H-3] SCH 23390 BINDING-SITES IN THE RAT STRIATUM AND LIMBIC SYSTEM
KLIMEK, V
NIELSEN, M
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 139 (02) : 163 - 169
[7] PERMISSIVE ROLE OF D-1 RECEPTOR STIMULATION BY ENDOGENOUS DOPAMINE FOR THE EXPRESSION OF POSTSYNAPTIC D-2-MEDIATED BEHAVIORAL-RESPONSES - YAWNING IN RATS
LONGONI, R
SPINA, L
DICHIARA, G
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 134 (02) : 163 - 173
[8] LOWRY OH, 1951, J BIOL CHEM, V193, P265
[9] LONG-TERM CHANGES IN SENSITIVITY OF PRESYNAPTIC AND POSTSYNAPTIC DOPAMINE RECEPTORS IN MOUSE STRIATUM EVIDENCED BY BEHAVIORAL AND BIOCHEMICAL STUDIES
MARTRES, MP
COSTENTIN, J
BAUDRY, M
MARCAIS, H
PROTAIS, P
SCHWARTZ, JC
[J]. BRAIN RESEARCH, 1977, 136 (02) : 319 - 337
[10] GUANOSINE TRIPHOSPHATE ACTIVATION OF BRAIN ADENYLATE-CYCLASE - ENHANCEMENT BY LONG-TERM ANTI-DEPRESSANT TREATMENT
MENKES, DB
RASENICK, MM
WHEELER, MA
BITENSKY, MW
[J]. SCIENCE, 1983, 219 (4580) : 65 - 67

← 1 2 →