GASTRIC MICROCIRCULATION AND ITS REGULATING FACTORS IN STRESS

被引：17

作者：

KITAJIMA, M ^{[1
]}

SHIMIZU, A ^{[1
]}

SAKAI, N ^{[1
]}

OTSUKA, S ^{[1
]}

MOGI, M ^{[1
]}

NAKAJIMA, M ^{[1
]}

KIUCHI, T ^{[1
]}

IKEDA, Y ^{[1
]}

OSHIMA, A ^{[1
]}

机构：

[1] KYORIN UNIV,SCH MED,DEPT SURG 1,MITAKA,TOKYO 181,JAPAN

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 1991年 / 13卷

关键词：

ACUTE GASTRIC MUCOSAL LESION; GASTRIC MICROCIRCULATION; ARTERIOVENULAR SHUNT; 5-HYDROXYTRYPTAMINE (5-HT); ISCHEMIA REPERFUSION;

D O I：

10.1097/00004836-199112001-00002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Gastric mucosal blood flow and its regulating factors were studied in normal and stressed rats. In addition, vascular regulating factors and the role of CoQ10 anion radical and SOD (superoxide dismutase) level in gastric mucosa were also investigated as well as the influence of 5-HT (5-hydroxytryptamine) on gastric mucosal blood flow. Gastric mucosal blood flow was measured by the hydrogen gas clearance method. The vascular pattern of the stomach was investigated by the infusion method with two-colored silicon rubber. CoQ10 anion radical and SOD levels in gastric tissue were assayed by electron spin resonance (ESR) and radioimmunoassay. The gastric mucosal blood flow decreased significantly early after the induction of stress. Impariment of gastric mucosal blood flow was highly correlated with 5-HT and CoQ10 anion radical and SOD levels. Reduction in gastric mucosal blood flow was consequently due to opening of arteriovenular shunt and hyperpermeability of true capillaries influenced by 5-HT. These results demonstrate that ischemia and reperfusion after reduction of the gastric mucosal blood flow resulted in the sequence of events that led to formation of acute gastric mucosal lesions.

引用

页码：S9 / S17

页数：9

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