A MODEL FOR THE INVOLVEMENT OF MHC CLASS-II PROTEINS IN THE DEVELOPMENT OF TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS IN RESPONSE TO BOVINE SERUM-ALBUMIN PEPTIDES

被引：27

作者：

ROBINSON, BH

DOSCH, HM

MARTIN, JM

AKERBLOM, HK

SAVILAHTI, E

KNIP, M

ILONEN, J

机构：

[1] HOSP SICK CHILDREN,RES INST,DEPT IMMUNOL,TORONTO M5G 1X8,ONTARIO,CANADA

[2] HOSP SICK CHILDREN,RES INST,DEPT PAEDIAT,TORONTO M5G 1X8,ONTARIO,CANADA

[3] UNIV TORONTO,TORONTO M5S 1A1,ONTARIO,CANADA

[4] UNIV HELSINKI,CHILDRENS HOSP,DEPT PAEDIAT 1,SF-00100 HELSINKI 10,FINLAND

[5] UNIV HELSINKI,DEPT PAEDIAT 2,SF-00100 HELSINKI 10,FINLAND

[6] UNIV OULU,DEPT PAEDIAT,SF-90100 OULU 10,FINLAND

[7] UNIV TURKU,DEPT VIROL,SF-20500 TURKU 50,FINLAND

来源：

DIABETOLOGIA | 1993年 / 36卷 / 04期

关键词：

D O I：

10.1007/BF00400243

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Considerations of the structure of a candidate initiating antigen have led us to propose a new model for the susceptibility to Type 1 diabetes. It is quite likely there are other antigens of similar structure of viral or bacterial origin that will provoke a similar response directed against islet beta cells. However, we believe that this hypothesis will provide a framework for the further investigation and research into the mechanism of development of Type 1 diabetes and for the design of therapeutic manoeuvres for its prevention. © 1993 Springer-Verlag.

引用

页码：364 / 368

页数：5

共 27 条

[1]

BEPPU H, 1987, DIABETES RES CLIN EX, V6, P67

[2]

BORCHJOHNSEN K, 1984, LANCET, V2, P1083

[3] A HYPOTHETICAL MODEL OF THE FOREIGN ANTIGEN-BINDING SITE OF CLASS-II HISTOCOMPATIBILITY MOLECULES [J].