ASYMMETRIC REDUCTION OF KETOESTERS WITH ALCOHOL-DEHYDROGENASE FROM THERMOANAEROBACTER-ETHANOLICUS

被引：15

作者：

ZHENG, C

PHAM, VT

PHILLIPS, RS

机构：

[1] Department of Chemistry, University of Georgia, Athens

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)81210-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The secondary alcohol dehydrogenase (SADH) of T. ethanolicus was produced by controlling the growth temperature at 50-degrees-C. Chiral hydroxyesters were obtained by the asymmetric reduction of ketoesters catalyzed by SADH. Reduction of ethyl levulinate gave (S)-gamma-butyrolactone in 84% yield and greater than 99% e.e..

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页码：619 / 622

页数：4

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