ALTERATION OF HUMAN PLATELET PROTEIN-KINASE-C WITH NORMAL AGING

被引：10

作者：

MATSUSHIMA, H

SHIMOHAMA, S

YAMAOKA, Y

KIMURA, J

TANIGUCHI, T

HAGIWARA, M

HIDAKA, H

机构：

[1] KYOTO UNIV,FAC MED,DEPT NEUROL,SAKYO KU,KYOTO 606,JAPAN

[2] KYOTO PHARMACEUT UNIV,DEPT NEUROBIOL,YAMASHINA KU,KYOTO 607,JAPAN

[3] NAGOYA UNIV,SCH MED,DEPT PHARMACOL,SHOWA KU,NAGOYA,AICHI 466,JAPAN

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1993年 / 69卷 / 1-2期

关键词：

PLATELET; PROTEIN KINASE-C; AGING;

D O I：

10.1016/0047-6374(93)90077-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Using a two-site enzyme immunoassay, we determined the content of type II protein kinase C (PKC) in human platelets from 24 donors of various ages without any neurological, hematological or malignant disorders. The content of type II PKC in the membranous fraction was positively correlated with aging. The content of PKC in the cytosolic fraction tended to decline with aging, but the correlation was not significant. The total amount of PKC also had no significant correlation with aging. Age-related changes in platelet protein content were not observed. These results suggested that the subcellular distribution of type II PKC in human platelets is altered with normal aging.

引用

页码：129 / 136

页数：8

共 22 条

[1] SEROTONIN UPTAKE IN THE BLOOD-PLATELETS OF ALZHEIMERS-DISEASE PATIENTS [J].