IS HUMAN PAPILLOMAVIRUS ASSOCIATED WITH CERVICAL NEOPLASIA IN THE ELDERLY

被引：13

作者：

MANDELBLATT, J

RICHART, R

THOMAS, L

CHAUHAN, P

MATSEOANE, S

KANETSKY, P

TRAXLER, M

LAKIN, P

机构：

[1] COLUMBIA PRESBYTERIAN MED CTR, DEPT PATHOL, NEW YORK, NY 10032 USA

[2] HARLEM HOSP MED CTR, DEPT PATHOL, NEW YORK, NY 10037 USA

[3] HARLEM HOSP MED CTR, DEPT OBSTET & GYNECOL, NEW YORK, NY 10037 USA

[4] HARLEM HOSP MED CTR, DEPT MED, NEW YORK, NY 10037 USA

[5] HARLEM HOSP MED CTR, DEPT NURSING, NEW YORK, NY 10037 USA

来源：

GYNECOLOGIC ONCOLOGY | 1992年 / 46卷 / 01期

关键词：

D O I：

10.1016/0090-8258(92)90187-N

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There have been no studies in the United States of human papillomavirus (HPV) in elderly women. This paper presents cross-sectional data on HPV and cervical neoplasia among 232 women age 65 or more. HPV deoxyribonucleic acid (DNA) testing was performed using a modified dot-blot hybridization technique. The prevalence of HPV DNA positivity was 3.5% (95% confidence interval (CI) 0.9%, 6.0%). There were six cases of histologic cervical neoplasia. The crude odds ratio for cervical neoplasia among HPV DNA positives was 18.3 (95% CI 2.8, 120.3). The adjusted odds, controlling for age, prior screening history, current sexual activity, and past contraception use, were 12.2 (95% CI 1.2, 122.9). Ever having had a Papanicolaou smear was protective, and there was a trend for the odds of having neoplasia to increase with age. Additional studies with larger samples of elderly women are needed. If confirmed, the results suggest that, independent of past screening, HPV may increase the risk of having cervical neoplasia for elderly women. © 1992.

引用

页码：6 / 12

页数：7

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