PHOSPHOINOSITIDE TURNOVER IN HUMAN PLATELETS IS STIMULATED BY ALBUMIN

被引：4

作者：

AMIN, RM ^{[1
]}

HAYS, JH ^{[1
]}

SHAKIR, KMM ^{[1
]}

机构：

[1] UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814

来源：

LIFE SCIENCES | 1991年 / 49卷 / 23期

关键词：

D O I：

10.1016/0024-3205(91)90313-Z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of human serum albumin (HSA) on the hydrolysis of phosphatidylinositides in human platelets labeled with myo(H-3)inositol was studied. Incubation of platelets with HSA (4 gm/dl) for 10 seconds increased IP2 and IP3 by 169% and 217% respectively. 93% of IP3 accumulated within the first 10 seconds. This effect was also shared by bovine serum albumin, although no changes in IP3 levels occurred with ovalbumin. All albumin species used induced Ca-45(+2) release from platelets irrespective of its effect on IP3 accumulation. These findings indicate that albumin may function in biological systems by inducing intracellular signaling.

引用

页码：1707 / 1719

页数：13

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