MITOTIC HYPERPLOIDY FOR CHROMOSOME-VIII AND CHROMOSOME-III IN SACCHAROMYCES-CEREVISIAE

被引：5

作者：

SPECTOR, LM ^{[1
]}

FOGEL, S ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT GENET & PLANT BIOL,BERKELEY,CA 94720

来源：

CURRENT GENETICS | 1992年 / 21卷 / 4-5期

关键词：

YEAST; ANEUPLOIDY; CHROMOSOMES;

D O I：

10.1007/BF00351688

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The arg4-8 and cup1S markers comprise a copy-number-dependent signal device in the yeast Sac-charomyces cerevisiae. These alleles permit reliable discrimination between euploid and disomic haploids as well as between euploid and trisomic diploids. To investigate and compare inherent inter-chromosomal differences as regards propensity for hyperploidy, we transplaced arg4-8 and cup1S by deleting them from chromosome VIII and then re-introducing them at the leu2 locus on chromosome III. The rate of chromosome gain was significantly greater for the chromosome III construct compared to the native chromosome VIII, in both diploid and haploid strains. In addition, more coincident aneuploidy for other chromosomes was found among chromosome VIII hyperploids compared to chromosome III hyperploids.

引用

页码：309 / 318

页数：10

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