THE ROLE OF RAS PROTEINS IN INSULIN SIGNAL TRANSDUCTION

被引：13

作者：

MAASSEN, JA ^{[1
]}

BURGERING, BMT ^{[1
]}

MEDEMA, RH ^{[1
]}

OSTEROP, APRM ^{[1
]}

VANDERZON, GCM ^{[1
]}

MOLLER, W ^{[1
]}

BOS, JL ^{[1
]}

机构：

[1] UNIV UTRECHT,DEPT PHYSIOL CHEM,UTRECHT,NETHERLANDS

来源：

HORMONE AND METABOLIC RESEARCH | 1992年 / 24卷 / 05期

关键词：

RAS; INSULIN RECEPTOR; MITOGENIC RESPONSE; GLUCOSE UPTAKE; INSULIN;

D O I：

10.1055/s-2007-1003296

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ras-proteins are guanine nucleotide binding proteins, which, in the GTP bound state emit a strong mitogenic signal. In the GDP bound state, the protein appears inactive. We have found that stimulation by insulin of cells expressing elevated levels of insulin receptors results in a rapid conversion of Ras-GDP into Ras-GTP. This process is part of the signalling pathway leading to immediate-early gene expression and a mitogenic response. There seems to be no involvement of Ras-GTP formation in the process of insulin stimulated glucose transport. Though the precise mechanism by which Ras is converted to the GTP bound state remains to be established, a tight correlation exists between receptor autophosphorylation and Ras-GTP formation.

引用

页码：214 / 218

页数：5

共 24 条

[1] THE LET-23 GENE NECESSARY FOR CAENORHABDITIS-ELEGANS VULVAR INDUCTION ENCODES A TYROSINE KINASE OF THE EGF RECEPTOR SUBFAMILY [J].