EFFECT OF ESTROGEN REPLACEMENT ON BONE METABOLISM AND CYTOKINES IN SURGICAL MENOPAUSE

被引：57

作者：

CANTATORE, FP

LOVERRO, G

INGROSSO, AM

LACANNA, R

SASSANELLI, E

SELVAGGI, L

CARROZZO, M

机构：

[1] Department of Rheumatology, University of Bari, Bari, 70124, Piazza G. Cesare

[2] Chair of Obstetric and Gynaecological Pathology 'R', University of Bari, Bari, 70124, Piazza G. Cesare

来源：

CLINICAL RHEUMATOLOGY | 1995年 / 14卷 / 02期

关键词：

ESTROGEN; CYTOKINES; OSTEOPOROSIS;

D O I：

10.1007/BF02214935

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of oestrogen replacement on bone metabolism and serum cytokine levels (IL1,IL6) was investigated in surgical menopause. The study included 40 female subjects; 10 healthy premenopausal women underwent total hysterectomy without oophorectomy. Thirty healthy premenopausal women underwent total hysterectomy with bilateral oophorectomy. They were randomly divided into 3 groups of 10 subjects. The first group received natural estradiol (0,05 mg/ day) for 6 months; the second group received natural estradiol (0,05 mg/day) and medroxyprogesteron acetate (10 mg/day) for 6 months, the third group received no therapy. Calcium-phosphorus metabolism, inflammatory indices, serum IL1 and IL6 levels were tested before and 6 months after surgery in all patients. A significant increase in serum alkaline phosphatase, urinary cross-links, serum PTH and IL1-IL6 was observed in the untreated women with total hysterectomy and oophorectomy. No significant variation in any of the parameters considered was observed in patients treated with oestrogen, in those treated with oestrogens and medroxyprogesteron nor in patients without oophorectomy. These results in human ''in vivo'' confirm that ovarian steroids play an important role in regulating the production of IL1 and IL6 which could regulate bone resorption.

引用

页码：157 / 160

页数：4

共 14 条

[1] Albrigh F.A., Bloomberg E., Smith P.H., Postmenopausal osteoporosis, Trans Assoc Am Physicians, 55, pp. 298-306, (1940)
[2] Dunrasma S.A., Raymakers J.A., Boereboom F.T.J., Scheven B.A.A., Estrogen and Bone Metabolism, Obstetrical and Gynecological Surgery, 47, pp. 38-44, (1991)
[3] Bijlsma J.W.J., Dunrsma S.A., Roclofs J.M.M., Thyroid function and bone turnover, Acta Endocrinol, 104, pp. 42-49, (1983)
[4] Canalis E., Effect of insulin-like growth factor I on DNA and protein synthesis in cultured rat calvaria, J Clin Invest, 66, pp. 709-715, (1980)
[5] Chambers T.J., Mc Schechy P.M.J., Thoon B.M., The effect of calcium-regulating hormones and prostaglandins on bone resorption by osteoclasts aggregated from neonatal rabbit bones, Endocrinology, 60, pp. 234-239, (1985)
[6] Pacifici R., Brown C., Puscheck E., Friedrich E., Slatopolosky E., Maggio D., Mc Gracken R., Avioli L., Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells, Proc Natl Acad Sci, 88, pp. 5134-5138, (1991)
[7] Jilka R.L., Hangoc G., Girasole G., Passeri G., Willia D.C., Abra J.S., Boyce B., Broxmeyer H., Manolagas S., Increased osteoclast development after estrogen loss: mediation by interleukin-6, Science, 257, pp. 88-91, (1992)
[8] Roodman G.D., Interleukin 6: An osteoporotic factor?, J Bone Clin Res, 7, pp. 475-478, (1992)
[9] Chandhary L.R., Spelsberg T.C., Riggs B.L., Production of various cytokines by normal human osteoblast-like cells in response to interleukin-1B and tumor necrosis factor alpha: lack of regulation by 17 beta-estradiol, Endocrinology, 130, pp. 2528-2534, (1992)
[10] Eriksen E.F., Colvard D.S., Bery N.J., Evidence of estrogen receptors in normal human osteoblast-like cells, Science, 241, pp. 84-88, (1988)

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