INFLUENCE OF SEX ON THE REACTIVITY TO ENDOTHELIN-1 AND NORADRENALINE IN SPONTANEOUSLY HYPERTENSIVE RATS

被引：12

作者：

FORTES, ZB

NIGRO, D

SCIVOLETTO, R

CARVALHO, MHC

机构：

[1] Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE | 1991年 / 13卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

SHR; ENDOTHELIN-1; NORADRENALINE;

D O I：

10.3109/10641969109042084

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The response to endothelin-1 and noradrenaline in isolated aortas in vitro and mesenteric arterioles in situ was studied in male and female spontaneously hypertensive rats (SHR). Greater sensitivity to endothelin-1 and noradrenaline and decreased reactivity to endothelin-1 but not to noradrenaline were found in aortas of male SHR. Mesenteric arterioles of male SHR were more sensitive to endothelin-1 and noradrenaline. Aortas and mesenteric arterioles of female SHR exhibited similar sensitivity to endothelin-1 as compared to controls, whereas a greater reactivity to this agent was only observed in microvessels. It is suggested that sex-linked alterations of vascular reactivity exist in SHR. These alterations seemed not to affect all vascular territories and were not due to differences in blood pressure levels of male and female SHR.

引用

页码：807 / 816

页数：10

共 11 条

[1]

ALTURA BM, 1975, J PHARMACOL EXP THER, V193, P403

[2]

BAEZ SILVIO, 1966, J APPL PHYSIOL, V21, P299

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