MICROBIAL TRANSFORMATIONS OF STEMODIN, A STEMODIA DITERPENE

被引：16

作者：

BADRIA, FA ^{[1
]}

HUFFORD, CD ^{[1
]}

机构：

[1] UNIV MISSISSIPPI,SCH PHARM,DEPT PHARMACOGNOSY,UNIVERSITY,MS 38677

来源：

PHYTOCHEMISTRY | 1991年 / 30卷 / 07期

关键词：

STEMODIA-MARITIMA; SCROPHULARIACEAE; MICROBIAL TRANSFORMATION; DITERPENE; STEMODIN; STEMODIN METABOLITES;

D O I：

10.1016/0031-9422(91)83626-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Screening studies have shown a number of microorganisms capable of transforming the stemodane diterpene, stemodin. Scale-up fermentation with Cunninghamella echinulata ATCC 9244 and Polyangium cellulosum ATCC 29610 have resulted in the production of five major metabolites that have been characterized with the use of 2D NMR techniques. These metabolites have been identified as 7-alpha-hydroxystemodin, 7-beta-hydroxystemodin, 14-alpha-hydroxystemodin, 19-hydroxystemodin and 17,19-dihydroxystemodin.

引用

页码：2265 / 2268

页数：4

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