SELECTIVITY AND MECHANISM OF ACTION OF NOVEL DNA-CLEAVING SULFONES

被引：66

作者：

NICOLAOU, KC

WENDEBORN, S

MALIGRES, P

ISSHIKI, K

ZEIN, N

ELLESTAD, G

机构：

[1] UNIV CALIF SAN DIEGO, DEPT CHEM, LA JOLLA, CA 92093 USA

[2] AMER CYANAMID CO, LEDERLE LABS, LEDERLE RES DIV, PEARL RIVER, NY 10965 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 04期

关键词：

D O I：

10.1002/anie.199104181

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple intercalating group like a naphthyl substituent increases the ability of unsaturated sulfones such as 1 to cleave DNA, as demonstrated by compounds 2 and 3. A selective attack on the guanine residue has been proven for 1. The mechanism of action of this class of compounds involves an alkylation reaction. (Figure Presented.) Copyright © 1991 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：418 / 420

页数：3

共 34 条

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