CONTRIBUTIONS OF THE LEFT INTRALAMINAR AND MEDIAL THALAMIC NUCLEI TO MEMORY - COMPARISONS AND REPORT OF A CASE

被引:70
作者
MENNEMEIER, M
FENNELL, E
VALENSTEIN, E
HEILMAN, KM
机构
[1] UNIV FLORIDA, COLL MED, DEPT CLIN & HLTH PSYCHOL, GAINESVILLE, FL 32610 USA
[2] DEPT VET AFFAIRS MED CTR, GAINESVILLE, FL USA
关键词
D O I
10.1001/archneur.1992.00530340070020
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A patient complained of memory disturbance after a small left thalamic infarction. Neuropsychological testing revealed her memory to be normal provided that she was allowed to rehearse or use semantic encoding strategies. When these strategies were prevented, her performance was impaired. Mapping of the lesion demonstrated involvement of the caudal intralaminar nuclei (centre median and parafascicular nuclei), and portions of the medial nuclei (medioventral [reuniens], centromedial, and the most inferior aspect of the mediodorsal nucleus). The majority of mediodorsal nucleus, the mammillary bodies, the mammillothalamic tract, and the anterior thalamic nuclei, were spared. A comparison among our patient's performances and those of alcoholic Korsakoff patients, patient NA, and amnestic patients with circumscribed diencephalic lesions suggests that there are two distinct behavioral and anatomic types of memory impairment associated with diencephalic lesions. The severe amnesia associated with damage to the mammillary bodies, midline nuclei, mammillothalamic tract, and/or dorsomedial nucleus of the thalamus (eg, Korsakoff and NA) is characterized by encoding deficits that never approximate normal performance. The memory disturbance associated with damage to the intralaminar and medial nuclei of the thalamus is milder and is characterized by severe distractibility.
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页码:1050 / 1058
页数:9
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