THE IMMUNE-HYPOTHALAMO-PITUITARY-ADRENAL AXIS AND AUTOIMMUNITY

被引：42

作者：

DERIJK, R ^{[1
]}

BERKENBOSCH, F ^{[1
]}

机构：

[1] FREE UNIV AMSTERDAM, FAC MED, DEPT PHARMACOL, VANDER BOECHORSTSTR 7, 1081 BT AMSTERDAM, NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 1991年 / 59卷 / 1-3期

关键词：

CYTOKINES; HYPOTHALAMO-PITUITARY-ADRENAL AXIS; AUTOIMMUNITY;

D O I：

10.3109/00207459108985452

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immunoendocrinology is a rapidly expanding field, uncovering numerous bilateral interactions between the immune system and neuroendocrine circuits. Various hormones and neurotransmitters appear to modulate cells of the immune system and likewise cytokines control the function of neuroendocrine system. In the present paper, we discuss some lines of evidence indicating that an immunoendocrine feedback loop, which we term "immune-hypothalamo-pituitary-adrenal system" is an integral part of the regulation of self tolerance. The finding that pathology of this immunoendocrine feedback loop is related to development of autoimmunity may lead to new prophylactic and therapeutic strategies. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：91 / 100

页数：10

共 78 条

[1] ADRENERGIC-MECHANISMS IN THE CONTROL OF CORTICOTROPIN SECRETION [J].