REGULATORY ROLE OF MICROSOMAL 3-HYDROXY-3-METHYLGLUTARYL-COENZYME-A REDUCTASE IN A TOBACCO MUTANT THAT OVERPRODUCES STEROLS

被引:57
作者
GONDET, L
WEBER, T
MAILLOTVERNIER, P
BENVENISTE, P
BACH, TJ
机构
[1] INST BOT, DEPT ENZYMOL CELLULAIRE & MOLEC, INST BIOL MOLEC PLANTES,CNRS,28 RUE GOETHE, F-67083 STRASBOURG, FRANCE
[2] UNIV KARLSRUHE, W-7500 KARLSRUHE, GERMANY
关键词
D O I
10.1016/0006-291X(92)90829-A
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In a tobacco mutant callus, containing up to tenfold more sterols than the wild-type genotype, HMG-CoA reductase activity is increased by a factor of approximately three, as is the case in mutant seedlings and plants. The rate of HMG-CoA synthesis from acetyl-CoA by the coupled enzyme system acetoacetyl-CoA thiolase/HMG-CoA synthase, as well as its conversion to acetyl-CoA plus acetoacetate by action of HMG-CoA lyase are not affected. These results confirm the key-regulating role of HMG-CoA reductase in sterol biosynthesis, which seems not to be confined only to the animal kingdom, but can also be extended to plants. © 1992.
引用
收藏
页码:888 / 893
页数:6
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