FLUORIDE CONCENTRATIONS IN PLAQUE, WHOLE SALIVA, AND DUCTAL SALIVA AFTER APPLICATION OF HOME-USE TOPICAL FLUORIDES

被引:75
作者
ZERO, DT [1 ]
RAUBERTAS, RF [1 ]
FU, J [1 ]
PEDERSEN, AM [1 ]
HAYES, AL [1 ]
FEATHERSTONE, JDB [1 ]
机构
[1] UNIV ROCHESTER,SCH MED & DENT,DEPT BIOSTAT,ROCHESTER,NY 14642
关键词
D O I
10.1177/00220345920710110201
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
It is now well-accepted that the primary anti-caries activity of fluoride (F) is via topical action. The retention of F in the mouth after topical fluoride treatment is considered to be an important factor in the clinical efficacy of F. The purpose of this study was to evaluate F levels in ductal saliva, whole saliva, and pooled plaque after treatment with topical F agents intended for home use. Ten consenting adults, mean (SD) age 31.0 (8.2) years, participated in all aspects of the study. Two days before each test, subjects received a professional tooth cleaning and subsequently abstained from all oral hygiene procedures to permit plaque to accumulate, and from the use of F-containing dental products. Treatments consisted of a placebo dentifrice (PD), fluoride dentifrice (FD; 0.24% NaF), fluoride rinse (FR; 0.05% NaF), and fluoride gel (FG; 1.1% NaF). Unstimulated whole saliva and pooled plaque were sampled at multiple points over a 24-hour period. In a separate experimental series, stimulated parotid saliva was sampled over a two-hour period after treatment. Fluoride levels generally followed the same pattern in whole saliva and pooled plaque samples, with FG > FR > FD > PD. Night-time F application resulted in prolonged F retention in whole saliva but not in plaque. Fluoride levels in parotid saliva were only slightly higher after F treatment and returned to baseline levels within two h. The results of this study indicate that the method of F delivery, the F concentration of the agent, and the time of application (daytime vs. night-time) are important factors influencing F levels in the mouth. The recycling of F in ductal saliva as a consequence of the inadvertent ingestion of home-use fluoride products does not appear to make a clinically significant contribution to F levels in the mouth.
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页码:1768 / 1775
页数:8
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